CAG Greater Copenhagen Research Centre for Systemic Low-Grade Inflammation
(LOGINFLAM)

The CAG LOGINFLAM aims to improve treatment for patients with diseases associated with low-grade inflammation (LGI). The CAG vision is to establish an internationally recognised centre of LGI research with a track record of excellent scientific results, education and innovation that has improved understanding of LGI-associated pathologies and contributed to a reduction of their individual and societal burden.

LGI is implicated in most noncommunicable diseases, e.g. type 2 diabetes, cardiovascular disease, periodontitis, neurodegenerative diseases and cancer. These diseases account for massive direct and indirect health costs; thus, LGI represents a substantial societal burden.

Also, traditional chronic inflammatory diseases, e.g. periodontitis, rheumatoid arthritis, primary Sjögren’s syndrome and systemic lupus erythematosus, as well as adverse effects of therapeutic interventions, e.g. transfusions or surgery, are linked with LGI. These diseases frequently share inflammatory pathways and coexist in individual patients, suggesting that treatment of one LGI-dependent disease may favourably affect another comorbidity.

While LGI research has attracted interest, clinical implementation of results has been limited. This is partly due to a predominant interest in conventional ‘disease-specific’ mechanisms and interventions, e.g. anti-diabetic or lipid-lowering drugs, and a belief that inflammatory mechanisms often are epiphenomena and not primary pathogenic drivers of disease. However, there is increasing realisation that even after optimal conventional treatment, persistent LGI represents a residual ‘inflammatory’ risk, and that inflammation is a maker and not merely a marker of disease.

The CAG aims to provide novel and clinically relevant data on the importance of LGI in human disease by adopting a translational approach based on a formalised collaboration between investigators from basic science, clinical specialties and epidemiology. By joining the forces of researches of proven excellence, the CAG creates synergies that promote high-quality LGI research, teaching, innovation and clinical implementation.

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CAG Chair

CAG Junior Chair

  • Christian Damgaard
    Christian Damgaard DDS PhD, Associate professor, Research area Periodontology, Section for Oral Biology and Immunopathology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen
  • Christian Enevold Senior post doc, MSc PhD, Head of section for molecular biology, Institute for Inflammation Research, sec. 7541, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Copenhagen

CAG Key Members

  • Henrik Vestergaard Senior Consultant, Associate Professor, Steno Diabetes Center Copenhagen, Endocrinology, the Capital Region of Denmark
  • Åsa Andersson Associate Professor, Halmstad University, School of Business, Engineering and Science, Rydberg Laboratory of Applied Sciences
  • Chantal Mathieu Professor, Katholieke Universiteit Leuven (KU LEUVEN), Laboratory of Clinical and Experimental Endocrinology
  • Søren Jacobsen Professor, Senior Consultant, the Capital Region of Denmark, Rigshospitalet, Copenhagen lupus ans VasculitisClinic, Center for Rheumatology and Spine Diseases
  • Anne Marie Lynge Pedersen Professor, Head of Department of Odontology, University of Copenhagen Department of Odontology
  • Peter Krustrup Professor, Head of Sport and Health Research, University of Southern Denmark, Faculty of Health Sciences, Department of Sports Science and Clinical Biomechanics
  • Lene Terslev Senior Consultant, Head of Rheumatological Iltrasound Unit, the Capital Region of Denmark, Rigshospitalet Glostrup, Copenhagen Center for Arthritis Research and Center for Rheumatology and Spine Diseases
  • Susanne Gjørup Sækmose Senior Consultant, Region Zealand, Næstved Hospital, Department of Clinical Immunology
  • Claus Henrik Nielsen Professor, Senior Consultant, Institute for Inflammation Research (IIR), Rigshospitalet, the Capital Region of Denmark
  • Susanne Brix Pedersen Professor MSO, DTU Bioengineering, Department of Biotechnology and Biomedicine, PSB-Disease Systems Immunology, Technical University of Denmark